Before Using Your Medicine
Tell your doctor before you start taking NEORAL if the answer
to any of the following questions is yes:
Do you suspect that you have had an allergic reaction to, or
been upset by any of the ingredients in NEORAL (listed in "WHAT'S IN
Do you have any kidney problems or have you had any disease,
which may have affected your kidneys?
Do you have high blood pressure?
Do you have an infection of any type?
Have you been told that you have any kind of tumour?
Do you have any liver problems or have you had any disease,
which may have affected your liver?
Have you been told that you have high levels of potassium in
your blood or that you have gout?
Do you have any skin conditions other than severe psoriasis or
Are you taking any other medicines (either bought or prescribed)?
Some medicines can interfere with your treatment, so make sure
to check with your doctor or pharmacist before taking any
other medicines. In particular, tell your doctor if you are
taking any of the following:
Antibiotics or antifungal medicines for treatment of infection
Oral contraceptive tablets
Any medicines for heart problems or high blood pressure
Cholesterol lowering medicines
Other immunosuppressive medicines (e.g. prednisolone)
Medicines to encourage urination
Anti-inflammatory medicines (i.e. NSAIDs) e.g. diclofenac
Light treatment (PUVA or other UV treatment) for your skin
Clarythromycin (an antibiotic used to treat infections)
Danazol (used to treat menstrual disorders, endometriosis and
Tacrolimus. Because tacrolimus "dampens down" your immune
system in a similar way to cyclosporin, if you take tacrolimus and
cyclosporin together your immune system may be "dampened down" too much.
If this happens you may be more likely to get infections.
St John's Wort: The herbal remedy St John's Wort (Hypericum
perforatum) should not be taken at the same time as this medicine. If
you already take St John's Wort, consult your doctor before stopping the
St John's Wort preparation.
Are you pregnant, or planning to become pregnant?
If you do become pregnant whilst taking NEORAL, tell your
Are you breast feeding?
Have you recently received any vaccinations or are you
planning to have any vaccinations?
Are you likely to be exposed to the sun a great deal without
protecting your skin with a sun block cream?
Do you regularly use a sun bed?
Taking Your Medicine
Your doctor will work out the correct dose of NEORAL for you
depending on your body weight and whether you are taking NEORAL
Your doctor will also tell you how often to take your
the total dose is usually no more than 5 mg/kg body weight per
lean body mass
Your doctor will adjust your dose to one that is ideal for
you. To do this he may need to do some blood tests.
Follow your doctor's instructions exactly and never change the
dose yourself, however well you feel.
Do not stop taking your medicine unless your doctor tells you
to, however well you feel.
Ask your doctor or pharmacist if you are unsure about how much
medicine to take or when to take it.
Remove the capsule from the foil as shown in the picture.
Place the capsule in your mouth. Take a mouthful of water,
then swallow the capsule whole. You may drink more water afterwards. Do
not eat grapefruit or drink grapefruit juice for 1 hour before taking
your dose as it may interfere with your medicine.
If you forget to take a dose, take another one as soon as you
remember, unless it is almost time for your next dose. Then go
on as before.
If you accidentally take too much of your medicine, tell your
doctor immediately, or go to your nearest casualty department.
After Taking Your Medicine
Most people benefit from taking this medicine, but a few
people can be upset by it.
First few weeks
The dose of this medicine needs to be carefully adjusted by
your doctor. Too much can affect the kidneys, the liver and blood
pressure. You will, therefore, have regular blood tests and visits to
the hospital. This will give you the chance to talk to your doctor about
your treatment and mention any problems you are having.
If you develop a sore throat, any infections or begin to feel
generally unwell see your doctor immediately.
Side-effects that have sometimes been reported in patients
taking cyclosporin include shakiness of the hands, upset stomach or
abdominal pain, tiredness and sensations of heat in the hands and feet.
After first few weeks
Swollen gums related to poor dental hygiene and exaggeration
of normal growth of hair on the body or face may occur.
More rarely, headaches, skin rash, increased weight, fluid
retention, confusion, feelings of numbness or tingling, muscle weakness
or cramps, fits, gout, raised cholesterol levels, slight swelling of the
breast tissue, changes in the menstrual period in women, and loss of
vision have also been reported.
In liver transplant patients, vision and movement
disturbances, and loss of concentration have also been reported as
side-effects. However, although these effects have been reported in
patients taking cyclosporin, they may not have actually been due to the
In the long run
There is a theoretical risk of malignancy (cancer) if you take
cyclosporin for many years. It appears to be mainly a problem for
patients who have had kidney transplants and is thought to be the result
of the transplanted kidney being infected with a virus that can cause
tumours. These are mainly tumours of the lymph glands (lymphomas). In
patients who take cyclosporin for eye problems there is no evidence of
an increased risk of lymphoma
Storing Your Medicine
Leave your capsules in the foil. Only remove them when it is
time to take your medicine.
It is important not to store your capsules in a hot place
(maximum temperature 25°C).
Store your medicine in a safe place where children cannot
reach it. Your medicine could harm them.
Do not use this medicine after the expiry date shown on the
If your doctor decides to stop your treatment, return any
leftover medicine to the pharmacist. Only keep it if your doctor tells